SERVICE

Contract development and manufacturing organization (CDMO) services for targeted and non-targeted drug nanoformulations.

There is no single universal method to encapsulate most drugs in nanocarriers. Each drug requires a highly individual approach to build up a stable and effective nanocarrier.

Rodos Biotarget developed know-how, protocols, and methods to formulate various drugs ranging from small molecule drugs to larger biomolecules in nanoparticles. By choosing between several formulation techniques, we help our customers to successfully formulate their valued molecules in lipid-based nanoparticles and to obtain stable nanocarriers with high active pharmaceutical ingredient (API) contents.

All types of liposomes and
other lipid-based drug delivery systems

Formulation of small molecules,
peptides/proteins, nucleic acids

targosphere-nanocarrier

Rodos also offers ready-made liposomes that can be loaded individually

Microfluidization, Extrusion, Dual Asymmetrical Centrifugation (DAC)
and others

For additional information about our services please also refer to the service and research guide issued by the Potsdam Science Park.

Please contact our business development team by email with your ideas and we will return to you immediately.

FORMULATION TECHNIQUES:

On a microfluidic chip, an organic phase, usually containing lipids, merges rapidly with an aqueous phase, triggering the spontaneous self-assembly of the lipids into unilamellar vesicles. Thereby, specifically engineered herringbone-like grooves strongly improve the mixing process. This technology enables precise manipulation of fluids and fluid interfaces at the micrometer scale and the self-assembly process can be controlled by varying liquid flow rates, ratios of cross-flows and concentration of components. Therefore, it is possible to tune the production of liposomes with desired features.

Extrusion is a standard technique to form lipid-based nanoparticles encapsulating a payload. By pressing a liposome suspension through a membrane filter of defined pore size, nanocarriers can be prepared. The extrusion process can be readily incorporated into a scaled-up manufacturing process to generate large volumes of formulation for industrial and medical applications.

Dual asymmetric centrifugation (DAC) technology allows the preparation of highly concentrated liposome solutions and efficient encapsulation of APIs. DAC differs from conventional centrifugation by an additional rotation of the sample around its own vertical axis. While the conventional centrifugation constantly pushes the sample material outwards, this additional rotation constantly forces the sample material towards the centre of the centrifuge. This unique combination of two contra rotating movements results in shear forces which lead to excellent homogenization of components. DAC allows the preparation of highly concentrated liposome solutions and with high API encapsulation efficiencies.

GET IN TOUCH

Rodos BioTarget GmbH

Medical Park Hannover

Feodor-Lynen-Str. 31
30625 Hannover / Germany

Telefon: +49 (511) 7273 8835
Telefax: +49 (511) 7273 8837

E-Mail: info@biotargeting.eu
www.biotargeting.eu

Potsdam Science Park

Am Mühlenberg 11
14476 Potsdam / Germany

Telefon: +49 (511) 7273 8835
Telefax: +49 (511) 7273 8837

E-Mail: info@biotargeting.eu
www.biotargeting.eu